Fundraising for my daughter Tanvi's bone marrow transplant - please come and help us!

My daughter, Baby Tanvi was developing fever when she was first hospitalized on 21st October 2014 at Columbia Asia Referral Hospital, Bangalore. Through investigations, she was diagnosed as a case of Primary HLH (Hemophagocytic Lymphohistiocytosis) and treated using HLH 2004 protocol for which she remained hospitalized till 1st-Jan-2015.

Later, we were referred for further treatment to Mazumdar Shaw medical Center (NH) for Bone Marrow Transplant under the care of Dr. Sunil Bhat. Tests were conducted on my wife, son and me to find suitability of bone marrow donor, but unfortunately allof us tested negative. Indian Directory and other countries Stem Cell organisations were also approached, but we did not get any suitable donor. The doctor then suggested us to go ahead with Haplo-Identical using TCR alpha /Betaand CD19 depletion technique with the Mother as donor. The estimated cost for the Haplo-Identicaltransplant treatment is Rs. 30 to 32 lakhs.

The Insurance Company too denied providing coverage / reimbursement, as HLH is caused to due to genetic issues and with effect from 21st October 2014 does not cover such cases. Till date, I have spent nearly Rs. 11 lakhs towards treatment, diagnosis and investigations for bone marrow treatment. I have been trying TO RAISE MONEY through various means but am finding it a very big challenge to arrange this huge amount. Whatever I had saved has been spent for this treatment andin addition I am now burdened with loans. I make a heartfelt request to kindly help me in treating my daughter. I shall be greatly indebted. The estimate has been attached for Haplo-Identical transplant treatment below.

Every contribution as little as Rs. 500 or more from you can help us. Please come forward and helpour 9 month old baby. If you cannot contribute for whatsoever reason, please share it on Facebook, Twitter or other social media platforms you use.

Hemanth Ganapathi K | +91 9886309249

The white clove remedy – GARLIC

- by Ashwini Jnanesha

 

The knowledge on health benefits of garlic dates back to ancient Hindu epics. An incident in the manuscripts quotes that drops of heavenly nectar were accidentally spilt on the Himalaya Mountains, and after a few days a small plant with the divine properties of the next was found growing. This plant was called ‘Rason’ meaning ‘king of rasas as it possesses five out of six tastes (taste, sweet, salt, pungent, bitter and astringent except sour). Rason is known as garlic in English, and its biological name is Allium sativum. For over years it has been used as a natural flavouring agent in cuisines and extensively used for its medicinal value. The potential health benefits of garlic reside in one of its natural component, allicin, a strong antimicrobial. Allicin is the main active component in garlic, which in turn forms the other active components of garlic accounting for a list of health benefits.


The Himalayan wonder Garlic is a natural garlic product devoid of preservatives or any processing. It is the only form of garlic with the potential to grow in the snowy mountains and withstand the freezing temperatures. It can be included as a nutritional supplement on daily basis.

Functional metabolites:

Alliin

Allicin

Allixin

Allyl polysulfides

Diallyl sulfide

Diallyl disulfude

Diallyl trisulfide

N-acetylcysteine

N-acetyl-S-allylcysteine

S-allylcysteine

S-allylmercaptocysteine

S-ethylcysteine

S-methylcysteine

S-propylcysteine

1,2-vinyldithiin

Thiacremonone

Therapeutic applications:

Anti microbial

Anti oxidant

Boosts immune system

Anti-clotting

Aphrodisiac

Pharmacological applications:

Conditions	Details
Bacterial infections
Fungal infections	Ringworm, jock itch, and athlete’s foot
Viral infections	Common cold
Cancer	Lowers the risk to most types of cancer
Cardiovascular disease	Lowering blood pressure, prevention of atherosclerosis, reduction of serum cholesterol and triglyceride, inhibition of platelet aggregation, and increasing fibrinolytic activity
High blood pressure
Rheumatism
Tuberculosis
Respiratory disorders	Asthma, bronchitis
Hip osteoarthritis
Iron uptake	Increases the production of body ferroportin

Side effects of garlic supplements (7):

Avoid garlic supplements (oral capsule/ tablet)

• In cases of allergic to garlic showing allergy symptoms like hives, difficult breathing, and swelling of your face lips, tongue, or throat.
• If planning to conceive
• If on lactation period
• If on certain prescribed medicines (in detail in garlic intervention section)
• If skin shows redness, swelling, or blistering when applied on skin
• If bleeding issues occur like nosebleeds, bleeding gums; also recommended to avoid supplements for at least two weeks before surgery and dental treatment as it hinders blood clotting
• If suffering for over bleeding during menstruation

Common side effects (on eating raw garlic):

• Unpleasant breath or body odor
• Heartburn, burning in your mouth or throat
• Nausea, vomiting, gas or
• Diarrhea

Latest studies on Garlic:

• Antibacterial activity: Allicin, a active constituent in garlic extracts shows potential antibacterial activity against E. coli, S. aureus and B. subtilis, at concentrations lower than that of the standard drug amoxicillin demonstrated by zone of inhibition test (9).
• Cardiovascular diseases: The organosulfur compounds in garlic metabolises into diallyl sulfide, diallyl disulfide, diallyl trisulfide, diallyl tetrasulfide, ajoene and S-allyl cysteines show a broad range of cardiovascular benefits. A meta-analysis study of 1,649 participants showed significant reduction in blood TC, LDL-C and FBG levels, along with SBP and DBP compared to control substance treated subjects (10).
• Ovarian cancer: Allicin activated JNK pathway in human ovarian cancer cell line SKOV3 resulting in cell apoptosis. The results were confirmed by action of SP600125, an inhibitor of JNK which blocked apoptosis of the cancer cells (11).
• Osteoarthritis: Diallyl disulphide (DADS), another active component of garlic is studied to show histone deacetylases (HDAC) inhibitor activity. The HDACs functions in activating the expression of MMPs, which degrades chondrocytes (12).
• Antiinflammatory activity: Alliin (S-allyl cysteine sulfoxide), an organosulfur compound of garlic significantly reduced the expression of proinflammatory genes, IL-6, MCP-1, and Egr-1 in 3T3-L1 adipocytes by modifying adipocyte metabolic profile (13).

Garlic supplement dosage (8):

The following doses have been studied in scientific research:
Oral dosage:

• For high blood pressure: Garlic extract 600-1200 mg divided and given three times daily.
• Aged garlic extract 600 mg to 7.2 grams per day has also been used.
• Fresh garlic 4 grams (approximately one clove) once daily has also been used.
• For prevention of colon, rectal, and stomach cancer: fresh or cooked garlic 3.5-29 grams weekly.

Application on skin:
For fungal skin infections (ringworm, jock itch, athlete’s foot): garlic ingredient ajoene as a 0.4% cream, 0.6% gel, and 1% gel applied twice daily for one week

Garlic relish

Garlic has made its way in culinaries around the globe as in pickles, pastas, salads, and forms of garlic breads, sauces, and the variety of curries of Asian countries. Studies have shown that the best way to retain the health benefits of garlic while cooking is to add crushed or chopped garlic just before finishing of the cooking process so as to not lose the allicin when stirred into foods at very high temperatures. Here are some picks on garlic infused menu around the globe.

Easy indian recipe

• Garlic pickle

Easy western recipe

• Lemon garlic dressing for salads
• Garlic bread
• Garlic infused pasta

Garlic supplements

Garlic bulbs are harvested and cool-dried to prevent allicin from forming until the garlic contacts water in the digestive tract. These are made available in market under different brands as tablets. They can be included as a daily supplement as per the supplier’s instruction included in the product. Some of the well known products are as below:

Product name	Details
Odor Control Garlic	Garlic — 1250 mg – 100 Tablets, Nature Made Odor Control Garlic Equivalent Dietary Supplement
Garlinase Fresh	4,000 mg of garlic – 100 Tablets
Garlic Bulb	Nature’s Way, Garlic Bulb, 580 mg, 100 Capsules
Kyolic aged garlic extract	Aged Garlic Extract™ [300 mg] (per capsule)
Once-Per-Day Garlic	Garlic Once-Per-Day Pure-Gar® Supplement; 6000 mcg of Allicin Yield and 13,200 mcg of Alliin.

Garlic intervention

A combination of certain medications along with garlic in diet hinders the absorption of the drug. Avoiding consumption of garlic when on these prescriptions results in effective absorption of the drug. Lists of such medications are:

Drug name	Disease treated
Isoniazid (INH, Nydrazid)	Tuberculosis
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)	HIV/AIDS
Saquinavir (Fortovase, Invirase)	HIV/AIDS
TriphasilOrtho-Novum 1/35, Ortho-Novum 7/7/7	Contraceptive pills
Cyclosporine (Neoral, Sandimmune)	Rheumatoid Arthritis, Psoriasis

Certain other medications metabolized in liver may be affected as garlic decreases their breakdown and results in increased side effects. Some such medications are:

Drug name	Conditions treated
Acetaminophen	Pain reliever and a fever reducer
Chlorzoxazone (Parafon Forte)	Painful musculoskeletal conditions
Theophylline	Asthma and COPD
Enflurane (Ethrane)	For anesthesia during surgery
Halothane (Fluothane)	For anesthesia during surgery
Isoflurane (Forane)	For anesthesia during surgery
Methoxyflurane (Penthrane)	For anesthesia during surgery
Diltiazem, nicardipine, verapamil	Calcium channel blockers for heart disorders
Etoposide, paclitaxel, vinblastine, vincristine, vindesine	Cancer drugs
Ketoconazole, itraconazole	Fungus-fighting drugs
Alfentanil (Alfenta)	For anesthesia during surgery
Cisapride (Propulsid)	Gastroesophageal reflux disease
Fentanyl (Sublimaze)	Potent narcotic analgesic
Lidocaine (Xylocaine)	Local anesthetic
Nifedipine (Adalat, Procardia)	High blood pressure
Isradipine (DynaCirc)	High blood pressure
Felodipine (Plendil)	High blood pressure
Amlodipine (Norvasc)	High blood pressure
Aspirin	Pain, fever, and inflammation
Clopidogrel (Plavix)	Slows blood clotting after heart attack and stroke
Diclofenac (Voltaren, Cataflam, others)	Pain, fever, and inflammation
Ibuprofen (Advil, Motrin, others)	Pain, fever, and inflammation
Naproxen (Anaprox, Naprosyn, others)	Pain, fever, and inflammation
Dalteparin (Fragmin)	Anticoagulant
Enoxaparin (Lovenox)	Anticoagulant
Heparin	Anticoagulant
Warfarin (Coumadin)	Anticoagulant

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KAVERI Theerthodbava to take place on October 17 2013 at 4.35 pm

Madikeri:

 

DC directs officials to make arrangements
Theerthodbava will take place at Talacauvery on October 17 at 4.35 pm, said Deputy Commissioner K H Ashwathanarayana Gowda.

 
Speaking at a meeting on Thursday, he directed the officials to make all preparations for the Tula sankramana fair. Last year, the responsibility of Theerthodbava was on the shoulder of Talacauvery-Bhagamandala Punar Prathishtapana committee. However, this year, everyone should join hands with the district administration in making the programme a success.

He said district-level officials should actively take part in the Tula sankramana. PWD, Zilla Panchayat engineering division, police, forest department Chescom, health department play a vital role in the success of Theerthodbava.

He directed PWD and Zilla Panchayat engineers to repair the road which lead to Bhagamandala by October 15. Barricades must be installed in Talacauvery.
DC directed DySP J D Prakash to make arrangement for the security, parking facilities in Talacauvery and Bhagamandala. Vehicle passes must be issued.

As large number of devotees visit Talacauvery and Bhagamandala on October 17 and 18, Chescom should provide uninterrupted power supply, he added.

Priority should be given to maintain cleanliness in Talacauvery-Bhagamandala. Washing of clothes, vehicles at Triveni sangama should not be allowed, he said.

DC directed temple committee to provide drinking water, space and other facilities for the distribution of food.

Temporary toilets must be constructed in Bhagamandala-Talacauvery. He directed DHO Dr Shivaram to provide ambulance, medical facilities at the spot.




Ban on liquor

Speaking on the occasion Akhila Kodava Samaja President Mathanda C Monnappa said Cauvery Sankramana is a holy moment for the people of the district. He appealed to the DC to ban the sale of liquor on October 17 and 18. Responding to it, he said sale of liquor will be banned from October 17, 6 am to October 18  at 6 pm in and around Bhagamandala.

Ban on plastic
DC directed Gram Panchayat Secretary to ban plastic in Talacauvery-Bhagamandala. Government will provide Rs 2 lakh towards Tula sankramana fair. Temple will provide a sum of Rs 6 lakh towards providing drinking water and publicity.

Talacauvery-Bhagamandala temple Punar Prathishtapana Committee honourary secretary G Rajendra said priority must be given for deploying additional buses, uninterrupted power supply and maintenance of cleanliness in the region.
ZP CEO Mirja Akbarulla said every gram panchayat will take up the responsibility of decorating the road from Madikeri to Bhagamandala. 


Zilla Panchayat Executive Engineer Keshavamurthy said that temporary arrangements will be made to provide drinking water at the venue.

Madikeri CMC President P D Ponnappa said if health department takes up the responsibility of construction and maintenance of temporary toilets, then personnel will be deployed by the CMC.

Additional DC Chandre Gowda, AC Akrampasha and others were present.
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Source- DH News Service

Kakkada Padhinett | Kakkada 18 in Kodagu / Coorg

Kakkada is a month in the Kodava calendar falling between July 17th and August 16th during the monsoon season amid heavy downpour, biting cold and dark cloud cover.

On the 18th day of kakkada, a sweet dish is prepared using the juice of a particular variety of plant called ‘maddh thopp’ which yields a dark purple juice when crushed. The juice is darkest during ‘kakkada’, indicating that its medicinal value is at its height. The dish is called ‘maddh kool’. It is believed that the plant has 18 kinds of medicinal values on the 18th day of ‘kakkada’. It is a tradition for every household to make ‘maddh kool’ on the 18th day of ‘kakkada’.

Kakkada is nothing but Ashada of the Kannadigas, Aati of the Tulvas and Aadi of the Tamils. The 18th day of Kakkada month is celebrated as the festival pertaining to Ayurvedic herbs. Kakkada month in Kodava calendar in Coorg, is one considered of the significant and auspicious days. aati soppu, kakkada paayasa

On the 18th day of “Kakkada” month, “maddhu soppu” a wild herb’s leaves are said to contain 18 varieties of herbal medicine as the plants emit a sweet aroma only on that day. Maddhu soppu is plucked and boiled in water to get the aromatic juice which will be in dark violet colour. Cakes and sweet porridge is prepared from this juice and consumed.

‘Kakkada koli' and ‘madd payasa' are the delicacies prepared on this day

How to Prepare “ madd toppu” or “ aati soppu” or “Kurunji toppu”

-          On the 18th day of the “ Kakkada” month, these leaves are said to be replete with 18 types of herbal medicines. They are plucked and soaked (some boil it) in water to extract the aromatic juice, which is thick and dark violet in colour. Women make cakes or sweet porridge out of the mix. Surprisingly, on the 18th day of “ Kakkada” , the plants start emitting a sweet and unique aroma that is not found on the plants prior to or after the 18th day. The traditional beliefs and social mores are very strong in Kodagu.

More on ‘Madd Toppu’: “Madd Toppu” (Justicia betonica) as it is called in Kodava parlance (“Aati Soppu” in Kannada) belongs to the family Acanthaceae, are 1.5 m tall plants, laves oblanceolate, acute, glabrous, petiole attenuate with blade 2.2–2.8 cm long. The plants are commonly found wild throughout the district, and some grow this at home. These are rich in saponins, vitamins, sugars, quinines, etc. The pinkish-violet extract that is obtained from boiling the leaves is separated and made into porridge, called “Madd Payasa,” in households on the 18th day of the Kakkada month. It is effective against fever, skin disease, ulcers, wounds, fracture, leucorrhoea, and few other diseases.

Kakkada in Coorg is a time to feast. Special dishes like mushroom and bamboo shoot curry (kanile curry), Crab curry are also preapared. As monsoon is the time when people fall sick due to cold usually these foods help to increase immunity and maintain body temperature.

Sources:
Gocoorg,orangecounty,gocoorg,thehindu,kodaguconnect